Piperazine and morpholine: Synthetic preview and pharmaceutical applications
نویسندگان
چکیده
This review summarizes the in vitro and in vivo medicinal chemistry investigations for piperazine and morpholine analogues. Piperazine and morpholine nucleus show a broad spectrum of pharmaceutical applications, thus, in recent years, scientists has developed various new methods for the synthesis of their derivatives. This review shows current tendency in the piperazine and morpholine analogues synthesis and reveals their potent pharmacophoric activities.
منابع مشابه
Surface active properties of simple cyclic and heterocyclic amines in water.
The surface tension of aqueous solutions of simple cyclic, heterocyclic and aromatic amines was measured with a Du Nöuy tensiometer at 25 degrees C and the results discussed in terms of structure-aggregation relationships. The simple compounds used in this study were piperazine, piperidine, morpholine, 3-methylpyridine, cyclohexylamine and benzylamine, with carbon numbers ranging from four to s...
متن کاملDe Novo Assembly of Highly Substituted Morpholines and Piperazines
The morpholine and piperazine with their remarkable physical and biochemical properties are popular heterocycles in organic and medicinal chemistry used in rational property design. However, in the majority of cases these rings are added to an existing molecule in a building block approach thus limiting their substitution pattern and diversity. Here we introduce a versatile de novo synthesis of...
متن کاملSynthesis and application of [1,2,5]triazepane and [1,2,5]oxadiazepane as versatile structural units for drug discovery.
Seven-membered heterocyclic [1,2,5]triazepane and [1,2,5]oxadiazepane derivatives were synthesized as candidate structures for application in drug discovery in place of conventional piperazine or morpholine moieties, offering multiple sites for modification with functional groups. We first synthesized the N-protected heterocycles, and then confirmed their utility by synthesizing analogues of th...
متن کاملStructures of piperazine, piperidine and morpholine.
The crystal structures of piperazine, piperidine and morpholine have been determined at 150 K. All three structures are characterized by the formation of NH...N hydrogen-bonded chains. In piperazine these are linked to form sheets, but the chains are shifted so that the molecules interleave. In morpholine there are in addition weak CH...O interactions. Topological analyses show that these three...
متن کاملExperimental and In-Silico Investigation of Anti-Microbial Activity of 1-Chloro-2-Isocyanatoethane Derivatives of Thiomorpholine, Piperazine and Morpholine
The Antibiogram properties of 1-chloro-2-isocyanatoethane derivatives of thiomorpholine (CTC), piperazine (CPC) and morpholine (CMC) were evaluated by the approved agar well diffusion, the minimum inhibitory concentration (MIC) and in silico techniques. A total of fourteen microbial cultures consisting of ten bacteria and four yeast strains were used in the biological study while affinity of th...
متن کامل